Why Jeff Bezos is backing this scientist working on a cure for aging

The desire to conquer aging is an old one. The National Institute on Aging was established by the National Institutes of Health in 1974. Nowadays it has a budget of about $2 billion. But that desire has grown stronger in the 21st century.

Some of the reason is out of necessity. The U.S. population is aging, and in about 10 years all the baby boomers will be older than 65, according to the U.S. Census Bureau. By 2035, older people will outnumber people under 18 for the first time in American history. Another reason comes straight from Silicon Valley. Over the last decade the titans of the tech industry — including Google and Facebook — have dedicated money toward cutting-edge research focused on curing disease as well as slowing, delaying and, possibly one day, reversing the conditions of old age.

Perhaps the most visible example is Calico, short for the California Life Company, a spin-out from Google launched in 2013 and funded with $1.5 billion to study the causes of aging and what to do about them. “People in Silicon Valley look at problems as solvable, with enough time and enough steps,” said Kevin Perrott, president of the Washington, D.C.-based Global Healthspan Policy Institute. “And, obviously, the size of the return is huge. If you’re able to bring anything like that to the market, you have something that’s universally needed.”

But defining what, precisely, is aging can be a tricky concept. In its simplest form, overall aging can be understood as cellular breakdown over time, which manifests itself in some of the common diseases of old age: diabetes, heart disease, Alzheimer’s, cancer, and so on. Designing a clinical trial around treating aging as a general condition is even more complicated, as most clinical trials approved by the Food and Drug Administration depend on measurable, observable outcomes.

“The study of aging, and the idea that you might be able to treat aging as a condition, is a novel area of research,” said an FDA spokesperson in an email. “A question not yet answered is how many age-related but otherwise independent diseases — coronary artery disease, dementia, sarcopenia, etc. — would need to be improved for us to consider the therapeutic effect an ‘anti-aging effect,’ rather than an effect on specific diseases.”

Unity Biotechnology CEO Keith Leonard said that why people experience aging, and then wrapping it into a product that can fit neatly into an FDA approval path, is still difficult — hence, the company’s approach on designing treatments for individual diseases. “The way we’ve chosen to do it instead is viewing aging through the diseases of aging that doctors know how to treat, and we attack those directly,” he said. “Now we know what kind of clinical trials to perform, with what patients, as well as what to measure and what kind of approval we can expect.”

Studying cellular senescence is just the starting point for some of those clinical trials, including the phase 1 osteoarthritis trial scheduled to last through the first quarter of 2019.

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